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Submit ReviewSR 16584
Description: Selective α3β4 nAChR antagonist
Chemical Name: 1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one
Purity: ≥98% (HPLC)
Biological Activity for SR 16584
SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM). Selectively binds α3β4 over α4β2 and α7 subtypes (Ki values are 0.508, >100 and >100 μM, respectively).
Technical Data for SR 16584
| M. Wt | 270.37 |
| Formula | C17H22N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1150153-86-8 |
| PubChem ID | 42602880 |
| InChI Key | GIDZCNCCCWFCIN-UHFFFAOYSA-N |
| Smiles | O=C(CC3=C2C=CC=C3)N2[C@H]1C[C@@H](N4C)CCC[C@@H]4C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 16584
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.04 | 100 |
Preparing Stock Solutions for SR 16584
The following data is based on the product molecular weight 270.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.7 mL | 18.49 mL | 36.99 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.7 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for SR 16584
References for SR 16584
References are publications that support the biological activity of the product.
Zaveri et al (2012) Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J.Med.Chem. 53 8187 PMID: 20979364
If you know of a relevant reference for SR 16584, please let us know.
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Keywords: SR 16584, SR 16584 supplier, SR16584, nAChRs, nicotinic, acetylcholine, receptors, a3b4, alpha3beta4, α3β4, antagonists, Nicotinic, Receptors, (Other, Subtypes), 4424, Tocris Bioscience
Citations for SR 16584
Citations are publications that use Tocris products.
Currently there are no citations for SR 16584. Do you know of a great paper that uses SR 16584 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.