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Submit ReviewSR 27897
Description: Potent and selective CCK1 antagonist
Alternative Names: Lintitript
Chemical Name: 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
Purity: ≥99% (HPLC)
Biological Activity for SR 27897
SR 27897 is a potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.
Compound Libraries for SR 27897
SR 27897 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SR 27897
| M. Wt | 411.86 |
| Formula | C20H14ClN3O3S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 136381-85-6 |
| PubChem ID | 122077 |
| InChI Key | ILNRQFBVVQUOLP-UHFFFAOYSA-N |
| Smiles | OC(=O)CN1C(=CC2=CC=CC=C12)C(=O)NC1=NC(=CS1)C1=CC=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 27897
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.59 | 50 |
Preparing Stock Solutions for SR 27897
The following data is based on the product molecular weight 411.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.86 mL | 24.28 mL | 48.56 mL |
| 2.5 mM | 0.97 mL | 4.86 mL | 9.71 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 25 mM | 0.1 mL | 0.49 mL | 0.97 mL |
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Product Datasheets for SR 27897
References for SR 27897
References are publications that support the biological activity of the product.
Gouldson et al (1999) Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 383 339 PMID: 10594328
Cano et al (2003) Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 140 647 PMID: 14534148
Gully et al (1993) Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol. 23 232
If you know of a relevant reference for SR 27897, please let us know.
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Keywords: SR 27897, SR 27897 supplier, Potent, selective, CCK1, antagonists, Cholecystokinin1, Receptors, CCK, Cholecystokinin, SR27897, Lintitript, Receptor, 2190, Tocris Bioscience
1 Citation for SR 27897
Citations are publications that use Tocris products. Selected citations for SR 27897 include:
Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417
Do you know of a great paper that uses SR 27897 from Tocris? Please let us know.
Reviews for SR 27897
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.