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Submit ReviewSR 9238
Description: Potent and selective LXR inverse agonist
Chemical Name: Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate
Purity: ≥98% (HPLC)
Biological Activity for SR 9238
SR 9238 is a potent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice.
Compound Libraries for SR 9238
SR 9238 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SR 9238
| M. Wt | 595.73 |
| Formula | C31H33NO7S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1416153-62-2 |
| PubChem ID | 71478195 |
| InChI Key | HDZWHJYZJWLTAG-UHFFFAOYSA-N |
| Smiles | CCOC(C1=CC=C(O1)CN(S(=O)(C2=C(C=C(C=C2C)C)C)=O)CC3=CC=C(C4=CC(S(C)(=O)=O)=CC=C4)C=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 9238
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.57 | 100 |
Preparing Stock Solutions for SR 9238
The following data is based on the product molecular weight 595.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.68 mL | 8.39 mL | 16.79 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.36 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.68 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets for SR 9238
References for SR 9238
References are publications that support the biological activity of the product.
Griffett et al (2013) A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem.Biol. 8 559 PMID: 23237488
If you know of a relevant reference for SR 9238, please let us know.
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Keywords: SR 9238, SR 9238 supplier, SR9238, potent, selective, LXR, inverse, agonist, liver, obesity, receptors, LXR-like, Receptors, 5854, Tocris Bioscience
2 Citations for SR 9238
Citations are publications that use Tocris products. Selected citations for SR 9238 include:
Bruschi et al (2019) PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells. Hepatol Commun 3 1191 PMID: 31497741
Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687
Do you know of a great paper that uses SR 9238 from Tocris? Please let us know.
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