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StemRegenin 1

Cat. No. 7086 Submit a Review Datasheet / COA / SDS
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Description: Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment
Chemical Name: 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for StemRegenin 1

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.

Technical Data for StemRegenin 1

M. Wt 429.54
Formula C24H23N5OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1227633-49-9
PubChem ID 46199207
InChI Key BGFHMYJZJZLMHW-UHFFFAOYSA-N
Smiles CC(N1C=NC2=C(N=C(C3=CSC4=CC=CC=C34)N=C12)NCCC5=CC=C(C=C5)O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for StemRegenin 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.95 100

Preparing Stock Solutions for StemRegenin 1

The following data is based on the product molecular weight 429.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets for StemRegenin 1

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for StemRegenin 1

References are publications that support the biological activity of the product.

Jackson et al (2017) Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 21 124 PMID: 28445828

Genovese et al (2014) Targeted genome editing in human repopulating haematopoietic stem cells. Nature 510 235 PMID: 24870228

Boitano et al (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329 1345 PMID: 20688981

Koide et al (2016) Aryl hydrocarbon receptor antagonist StemRegenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4. Anticancer Res. 36 3635 PMID: 27354634

If you know of a relevant reference for StemRegenin 1, please let us know.

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Citations for StemRegenin 1

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