STF 083010

Discontinued Product

4509 has been discontinued.

View all IRE1 products.
Description: Inhibits IRE1α endonuclease activity
Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity for STF 083010

STF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

Technical Data for STF 083010

M. Wt 317.38
Formula C15H11NO3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 307543-71-1
PubChem ID 11487816
InChI Key RAKGNVNONBJBSW-UHFFFAOYSA-N
Smiles OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for STF 083010

References are publications that support the biological activity of the product.

Papandreou et al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311 PMID: 21081713

Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53 PMID: 22112465

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Keywords: STF 083010, STF 083010 supplier, STF083010, IRE1alpha, IRE1a, IRE1α, inhibitors, inhibits, endonucleases, RNases, XBP, mRNA, splicing, inositol, requiring, enzyme, endoplasmic, reticulum, IRE1, 4509, Tocris Bioscience

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
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