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Submit ReviewSTX 64
Description: Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II
Chemical Name: 6,7,8,9,10,11-Hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl sulfamate
Purity: ≥98% (HPLC)
Biological Activity for STX 64
STX 64 is a potent steroid sulfatase inhibitor (IC50 = 8 nM). Estrone sulfate-stimulated uterine growth and mammary tumor growth are inhibited by STX 64 in animal models. STX 64 shows inhibition of steroid sulfatase activity in peripheral blood lymphocytes, liver and tumor tissues and is active in vivo. STX 64 is also a potent inhibitor of carbonic anhydrase II (IC50 = 25 nM).
Compound Libraries for STX 64
STX 64 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for STX 64
| M. Wt | 309.34 |
| Formula | C14H15NO5S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 288628-05-7 |
| PubChem ID | 5287541 |
| InChI Key | DSLPMJSGSBLWRE-UHFFFAOYSA-N |
| Smiles | O=C1OC=2C=C(OS(=O)(=O)N)C=CC2C3=C1CCCCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for STX 64
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.93 | 100 | |
| ethanol | 3.09 | 10 |
Preparing Stock Solutions for STX 64
The following data is based on the product molecular weight 309.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.23 mL | 16.16 mL | 32.33 mL |
| 5 mM | 0.65 mL | 3.23 mL | 6.47 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.23 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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Product Datasheets for STX 64
References for STX 64
References are publications that support the biological activity of the product.
Ho et al (2003) Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochem.Biophys.Res.Commun. 305 909 PMID: 12767917
Purohit et al (2000) In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 60 3394 PMID: 10910045
Raobaikady et al (2003) Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. J.Steroid Biochem.Mol.Biol. 84 351 PMID: 12711022
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Keywords: STX 64, STX 64 supplier, STX64, potent, steroid, sulfatase, inhibitors, inhibits, esterases, tumor, carbonic, anhydrase, EC3.1.6.2, steryl-sulfatase, Other, Hydrolases, Carbonic, anhydrases, 7341, Tocris Bioscience
Citations for STX 64
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