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Description: Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable
Chemical Name: N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide
Purity: ≥98% (HPLC)
Biological Activity for T 3364366
T 3364366 is a potent and reversible fatty acid desaturase 1 (FADS1; Δ5 desaturase) inhibitor (IC50 values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ6 desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.
Compound Libraries for T 3364366
T 3364366 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for T 3364366
| M. Wt | 443.46 |
| Formula | C18H16F3N3O3S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1356354-09-0 |
| PubChem ID | 86685411 |
| InChI Key | BVRXQXNVDLUWMV-UHFFFAOYSA-N |
| Smiles | CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(C=C3)OCC(F)(F)F)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for T 3364366
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.35 | 100 |
Preparing Stock Solutions for T 3364366
The following data is based on the product molecular weight 443.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.25 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets for T 3364366
References for T 3364366
References are publications that support the biological activity of the product.
Miyahisa et al (2016) T-3364366 targets the desaturase domain of delta-5 desaturase with nanomolar potency and a multihour residence time. ACS Med.Chem.Lett. 7 868 PMID: 27660693
If you know of a relevant reference for T 3364366, please let us know.
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Keywords: T 3364366, T 3364366 supplier, T3364366, FADS1, inhibitors, inhibits, potent, reversible, delta5, desaturase, arachidonic, acid, anti-inflammatory, acyl-lipid(8-3), Other, Lipid, Metabolism, Oxygenases/Oxidases, 6106, Tocris Bioscience
Citations for T 3364366
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