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TAC

Cat. No. 8825 Submit a Review Datasheet / COA / SDS
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Description: TERT activator
Chemical Name: N-(3-Chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TAC

TAC is a telomerase reverse transcriptase (TERT) activator. TAC upregulates TERT gene transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC enhances telomere synthesis, reduces tissue aging markers, cellular senescence, and inflammatory cytokines. In the brain, TAC induces neurogenesis, reduces neuroinflammation, and preserves cognitive function.

Technical Data for TAC

M. Wt 331.76
Formula C14H12ClF2NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 666699-46-3
PubChem ID 2805068
InChI Key JVUSVLUQMXGABO-UHFFFAOYSA-N
Smiles O=S(NC1=CC=C(C(Cl)=C1)F)(C2=CC(C)=C(F)C(C)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAC

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.18 100
ethanol 33.18 100

Preparing Stock Solutions for TAC

The following data is based on the product molecular weight 331.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for TAC

References are publications that support the biological activity of the product.

Shim et al (2024) TERT activation targets DNA methylation and multiple aging hallmarks. Cell 187 4030 PMID: 38908367

If you know of a relevant reference for TAC, please let us know.

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Citations for TAC

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