Home / Pharmacology / Enzymes / Hydrolases / Fatty Acid Amide Hydrolase / Fatty Acid Amide Hydrolase Inhibitors / TAK 21d

TAK 21d

Cat. No. 5209 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent FAAH inhibitor
Chemical Name: 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TAK 21d

TAK 21d is a potent FAAH inhibitor; (IC50 values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.

Technical Data for TAK 21d

M. Wt 397.38
Formula C19H17F2N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1143578-94-2
PubChem ID 57749996
InChI Key JCWVFSJNIBAGQN-UHFFFAOYSA-N
Smiles FC1=CC(C2=NC(N3CCN(C(NC4=CC=CN=N4)=O)CC3)=NC=C2)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAK 21d

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.97 10
1eq. HCl 7.95 20

Preparing Stock Solutions for TAK 21d

The following data is based on the product molecular weight 397.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.58 mL 62.91 mL 125.82 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
2 mM 1.26 mL 6.29 mL 12.58 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

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References for TAK 21d

References are publications that support the biological activity of the product.

Kono et al (2014) Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 22 1468 PMID: 24440478

If you know of a relevant reference for TAK 21d, please let us know.

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Citations for TAK 21d

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Currently there are no citations for TAK 21d. Do you know of a great paper that uses TAK 21d from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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