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Submit ReviewTalampanel
Description: Non-competitive non-NMDA iGluR antagonist
Alternative Names: GYKI 53773,LY 300164
Chemical Name: (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Purity: ≥98% (HPLC)
Biological Activity for Talampanel
Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
Compound Libraries for Talampanel
Talampanel is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Talampanel
| M. Wt | 337.37 |
| Formula | C19H19N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 161832-65-1 |
| PubChem ID | 164509 |
| InChI Key | JACAAXNEHGBPOQ-LLVKDONJSA-N |
| Smiles | NC(C=C4)=CC=C4C1=NN(C(C)=O)[C@H](C)CC2=C1C=C(OCO3)C3=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Talampanel
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.74 | 100 |
Preparing Stock Solutions for Talampanel
The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.64 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for Talampanel
References for Talampanel
References are publications that support the biological activity of the product.
Czuczwar et al (1998) LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 359 103 PMID: 9832379
Borowicz et al (2000) The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of D.pam. Naunyn-Schmied.Arch.Pharmacol. 361 629 PMID: 10882038
Belayev et al (2001) Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 18 1031 PMID: 11686490
If you know of a relevant reference for Talampanel, please let us know.
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Keywords: Talampanel, Talampanel supplier, GYKI53773, LY300164, non-competitive, AMPA/Kainate, antagonists, Glutamate, Receptors, iGlur, Ionotropic, GYKI, 53773, LY, 300164, AMPA, Kainate, 5032, Tocris Bioscience
Citations for Talampanel
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