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Description: Inhibitor of smooth muscle cell migration and proliferation
Chemical Name: 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Purity: ≥99% (HPLC)
Biological Activity for TAS 301
TAS 301 is an inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.
Technical Data for TAS 301
| M. Wt | 357.4 |
| Formula | C23H19NO3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 193620-69-8 |
| PubChem ID | 9885087 |
| InChI Key | KUEYYIJXBRWZIB-UHFFFAOYSA-N |
| Smiles | O=C2NC1=CC=CC=C1/C2=C(C4=CC=C(OC)C=C4)\C3=CC=C(OC)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TAS 301
References for TAS 301
References are publications that support the biological activity of the product.
Muranaka et al (1998) TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J.Pharmacol.Exp.Ther. 285 1280 PMID: 9618434
Sasaki et al (2000) TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn.J.Pharmacol. 84 252 PMID: 11138725
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Keywords: TAS 301, TAS 301 supplier, TAS301, smooth, muscles, cells, migration, proliferation, blockers, inhibitors, inhibits, voltage-independent, calcium, influx, neointimal, thickening, stenosis, angioplasty, restenosis, Miscellaneous, Compounds, 4521, Tocris Bioscience
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