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Submit ReviewTB 21007
Description: α5-selective GABAA inverse agonist
Chemical Name: 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
Purity: ≥99% (HPLC)
Biological Activity for TB 21007
TB 21007 is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
Technical Data for TB 21007
| M. Wt | 339.5 |
| Formula | C15H17NO2S3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 207306-50-1 |
| PubChem ID | 6918633 |
| InChI Key | QILRYFCEXLFIDS-UHFFFAOYSA-N |
| Smiles | O=C2C1=C(SCCO)SC(C3=NC=CS3)=C1CC(C)(C)C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TB 21007
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.95 | 100 | |
| ethanol | 8.49 | 25 |
Preparing Stock Solutions for TB 21007
The following data is based on the product molecular weight 339.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.73 mL | 29.46 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets for TB 21007
References for TB 21007
References are publications that support the biological activity of the product.
Chambers et al (2003) Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 46 2227 PMID: 12747794
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Keywords: TB 21007, TB 21007 supplier, α5, alpha5-selective, GABAA, inverse, agonists, Receptors, TB21007, 2905, Tocris Bioscience
2 Citations for TB 21007
Citations are publications that use Tocris products. Selected citations for TB 21007 include:
De la Luz-Cuellar et al (2019) Blockade of spinal α5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats. Eur J Pharmacol 858 172443 PMID: 31181208
Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Clin Invest 64 145 PMID: 22732440
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.