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Description: Potent, reversible and selective FAAH inhibitor
Chemical Name: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Biological Activity for TC-F 2
TC-F 2 is a potent, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 values are 28 and 100 nM for human and rat FAAH respectively). Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC50 > 20 μM for CB1, CB2 and TRPV1). Active in vivo.
Compound Libraries for TC-F 2
TC-F 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for TC-F 2
| M. Wt | 439.51 |
| Formula | C26H25N5O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1304778-15-1 |
| PubChem ID | 25198728 |
| InChI Key | NXTBLPPTZRPJCA-IBGZPJMESA-N |
| Smiles | O=C(N(CC)C6=C5C=CC=C6)N5[C@H]1CCCN(C2=NC(C3=CC(C=CC=C4)=C4O3)=CC=N2)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-F 2
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.95 | 100 |
Preparing Stock Solutions for TC-F 2
The following data is based on the product molecular weight 439.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.38 mL | 22.75 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.55 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for TC-F 2
References for TC-F 2
References are publications that support the biological activity of the product.
Min et al (2011) Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc.Natl.Acad.Sci.U.S.A. 108 7379 PMID: 21502526
Gustin et al (2011) Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett. 21 2492 PMID: 21392988
If you know of a relevant reference for TC-F 2, please let us know.
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Keywords: TC-F 2, TC-F 2 supplier, TCF2, TC-F2, fatty, acid, amide, hydrolase, FAAH, inhibits, inhibitors, reversible, noncovalent, potent, in, vivo, selective, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4355, Tocris Bioscience
Citations for TC-F 2
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Currently there are no citations for TC-F 2. Do you know of a great paper that uses TC-F 2 from Tocris? Please let us know.
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Literature in this Area
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