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Description: Potent and selective A2A antagonist
Chemical Name: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide
Purity: ≥98% (HPLC)
Biological Activity for TC-G 1004
TC-G 1004 is a potent antagonist of adenosine A2A receptors; displays >100-fold selectivity for A2A over A1 receptors (Ki values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.
Technical Data for TC-G 1004
| M. Wt | 421.5 |
| Formula | C22H27N7O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1061747-72-5 |
| PubChem ID | 25074316 |
| InChI Key | JENSDTKXNVHSSN-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=NN1C2=NC(C3=CC=CC(N4CCC(OC)CC4)=N3)=CC(NC(C)=O)=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-G 1004
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 42.15 | 100 | |
| DMSO | 42.15 | 100 |
Preparing Stock Solutions for TC-G 1004
The following data is based on the product molecular weight 421.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.86 mL | 23.72 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for TC-G 1004
References for TC-G 1004
References are publications that support the biological activity of the product.
Zhang et al (2008) Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J.Med.Chem. 51 7099 PMID: 18947224
If you know of a relevant reference for TC-G 1004, please let us know.
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Keywords: TC-G 1004, TC-G 1004 supplier, TC-G1004, adenosine, A2A, receptors, selective, potent, antagonists, Adenosine, Receptors, 4407, Tocris Bioscience
Citations for TC-G 1004
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.