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Submit ReviewTC-I 2000 is a tRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM).
TC-I 2000 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 414.4 |
Formula | C23H18F4N2O |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 1159996-20-9 |
PubChem ID | 57326210 |
InChI Key | ADCDUDFEGFKKQH-UHFFFAOYSA-N |
Smiles | O=C(NC3=CC=C(F)C=C3)N2C(C4=CC=C(C(F)(F)F)C=C4)C1=CC=CC=C1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 41.44 | 100 | |
ethanol | 8.29 | 20 |
The following data is based on the product molecular weight 414.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
References are publications that support the biological activity of the product.
Tamayo et al (2012) Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 55 1593 PMID: 22329507
If you know of a relevant reference for TC-I 2000, please let us know.
Keywords: TC-I 2000, TC-I 2000 supplier, TCI2000, TRPM8, transient, receptor, potential, channels, blockers, TRPM, 4632, Tocris Bioscience
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