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Submit ReviewTC-T 6000
Description: Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor
Chemical Name: 2,2'-[[4,8-Bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino]bis-ethanol
Purity: ≥98% (HPLC)
Biological Activity for TC-T 6000
Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor (IC50 = 74.4 nM). Exhibits 20-fold and 80-fold selectivity for ENT4 over ENT2 and ENT1, respectively.
Technical Data for TC-T 6000
| M. Wt | 504.71 |
| Formula | C26H48N8O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 949467-71-4 |
| PubChem ID | 16757265 |
| InChI Key | KIZLZYHFIWWKIL-UHFFFAOYSA-N |
| Smiles | CC(C)CN(CC(C)C)C2=NC(NCCO)=NC1=C(N(CC(C)C)CC(C)C)N=C(NCCO)N=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-T 6000
References for TC-T 6000
References are publications that support the biological activity of the product.
Wang et al (2013) Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem.Pharmacol. 86 1531 PMID: 24021350
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Keywords: TC-T 6000, TC-T 6000 supplier, potent, selective, ENT4, inhibitors, inhibits, equilibrative, nucleoside, transporter, 4, Nucleoside, Transporters, 5100, Tocris Bioscience
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