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Submit ReviewTCN 237 dihydrochloride
Description: Highly potent and selective GluN2B NMDA antagonist
Chemical Name: 2-[[4-[(2-Fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-ol dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for TCN 237 dihydrochloride
TCN 237 dihydrochloride is a highly potent GluN2B (formally NR2B) selective NMDA receptor antagonist (Ki = 0.8 nM); blocks GluN2B-mediated calcium influx in Ltk cells (Ki = 9.7 nM). Selective for GluN2B subunit over α1-adrenergic receptors and hERG channels (IC50 values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for TCN 237 dihydrochloride
| M. Wt | 412.33 |
| Formula | C20H22FN3O.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 700878-19-9 |
| PubChem ID | 90488908 |
| InChI Key | JYUWGWCFJMDMND-UHFFFAOYSA-N |
| Smiles | FC1=CC=CC=C1CC(CC4)CCN4CC3=NC2=CC=C(O)C=C2N3.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCN 237 dihydrochloride
References for TCN 237 dihydrochloride
References are publications that support the biological activity of the product.
McCauley et al (2004) NR2B-selective N-MthD.-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J.Med.Chem. 47 2089 PMID: 15056006
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