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Submit ReviewTCS 1105
Description: GABAA α2 benzodiazepine agonist
Chemical Name: N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide
Purity: ≥99% (HPLC)
Biological Activity for TCS 1105
GABAA benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.
Technical Data for TCS 1105
| M. Wt | 296.3 |
| Formula | C17H13FN2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 185391-33-7 |
| PubChem ID | 2986030 |
| InChI Key | VWCCHJFFYCGXFL-UHFFFAOYSA-N |
| Smiles | O=C(C(NCC3=CC=C(F)C=C3)=O)C2=CNC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCS 1105
References for TCS 1105
References are publications that support the biological activity of the product.
Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723 PMID: 19469479
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Keywords: TCS 1105, TCS 1105 supplier, TCS1105, alpha2, agonist, alpha1, antagonist, GABA, a1, a2, α2, α1, GABAA, benzodiazepine, receptor, BZR, Receptors, 3942, Tocris Bioscience
Citations for TCS 1105
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Currently there are no citations for TCS 1105.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.