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Submit ReviewTCS HDAC6 20b
Description: Selective HDAC6 inhibitor
Chemical Name: 2-Methylpropanethioic acid-S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester
Purity: ≥98% (HPLC)
Biological Activity for TCS HDAC6 20b
TCS HDAC6 20b is a selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol (Cat. No. 1097). Also inhibits growth of MCF-7 cells stimulated by estrogen.
Technical Data for TCS HDAC6 20b
| M. Wt | 480.7 |
| Formula | C26H44N2O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 956154-63-5 |
| PubChem ID | 23636017 |
| InChI Key | DQZMLPMCOMRJOR-MOVGKWKRSA-N |
| Smiles | O=C([C@@H](NC(OC(C)(C)C)=O)CCCCCSC(C(C)C)=O)NC1(CC3C2)CC(C3)CC2C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCS HDAC6 20b
References for TCS HDAC6 20b
References are publications that support the biological activity of the product.
Itoh et al (2007) Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J.Med.Chem. 50 5425 PMID: 17929798
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Keywords: TCS HDAC6 20b, TCS HDAC6 20b supplier, TCSHDAC620b, histone, deacetylase, 6, HDAC6, inhibitors, inhibits, selective, Class, II, HDACs, 4805, Tocris Bioscience
1 Citation for TCS HDAC6 20b
Citations are publications that use Tocris products. Selected citations for TCS HDAC6 20b include:
Xiaojun et al (2016) Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica. Sci Rep 6 32257 PMID: 27577858
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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