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Description: Soluble adenylyl cyclase inhibitor
Chemical Name: (3R)-4-[2-[2-[[3-(2-Amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-3-morpholinemethanol
Purity: ≥98% (HPLC)
Biological Activity for TDI 11861
TDI 11861 is a potent and selective soluble adenylyl cyclase (sAC) inhibitor (IC50 values are 3.3 nM and 5.5 nM in biochemical and cellular assays, respectively; Kd = 1.4 nM). Inhibits cellular sAC-specific cAMP accumulation (IC50 = 7 nM) and blocks sperm capacitation in vitro. Cell permeable, not cytotoxic and suitable for both in vivo and in vitro use.
Licensing Information
Sold under license from Cornell University
Technical Data for TDI 11861
| M. Wt | 494.93 |
| Formula | C22H25ClF2N6O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2857049-72-8 |
| PubChem ID | 166101565 |
| InChI Key | XVGSKZXXLKUEIO-MRXNPFEDSA-N |
| Smiles | FC(F)N1N=C(C2=NC(N)=NC(Cl)=C2)C(CC3=C(C=CC=C3)OCCN4[C@@H](COCC4)CO)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TDI 11861
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.49 | 100 | |
| ethanol | 49.49 | 100 |
Preparing Stock Solutions for TDI 11861
The following data is based on the product molecular weight 494.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.02 mL | 10.1 mL | 20.2 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 10 mM | 0.2 mL | 1.01 mL | 2.02 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for TDI 11861
References for TDI 11861
References are publications that support the biological activity of the product.
Miller et al (2022) Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates. J.Med.Chem. 65 15208 PMID: 36346696
Balbach et al (2023) On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat.Commun. 14 637 PMID: 36788210
If you know of a relevant reference for TDI 11861, please let us know.
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Keywords: TDI 11861, TDI 11861 supplier, TDI11861, soluble, adenylyl, cyclase, inhibitor, inhibitors, inhibits, sAC, potent, selective, cell, permeable, Adenylyl, Cyclase, 8036, Tocris Bioscience
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