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Submit ReviewTelenzepine dihydrochloride
Description: Potent, selective M1 antagonist
Chemical Name: 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Telenzepine dihydrochloride
Telenzepine dihydrochloride is a selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Inhibits gastric acid secretion.
Technical Data for Telenzepine dihydrochloride
| M. Wt | 443.39 |
| Formula | C19H22N4O2S.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 147416-96-4 |
| PubChem ID | 6419995 |
| InChI Key | JTQJFSQQHGPLOX-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CN1CCN(CC(=O)N2C3=C(C)SC=C3C(=O)NC3=C2C=CC=C3)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Telenzepine dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.34 | 100 |
Preparing Stock Solutions for Telenzepine dihydrochloride
The following data is based on the product molecular weight 443.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets for Telenzepine dihydrochloride
References for Telenzepine dihydrochloride
References are publications that support the biological activity of the product.
Christofi et al (1991) Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 195 333 PMID: 1868879
Eltze et al (1985) Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 112 211 PMID: 4029260
Galvan et al (1989) Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 167 1 PMID: 2776837
If you know of a relevant reference for Telenzepine dihydrochloride, please let us know.
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Keywords: Telenzepine dihydrochloride, Telenzepine dihydrochloride supplier, Potent, selective, M1, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, 1122, Tocris Bioscience
1 Citation for Telenzepine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Telenzepine dihydrochloride include:
Pediani et al (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem. 291 13132 PMID: 27080256
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