Home / Pharmacology / Enzymes / Isomerases / DNA Topoisomerases / DNA Topoisomerase Inhibitors / Teniposide

Teniposide

Cat. No. 6975 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: DNA topoisomerase II inhibitor; viral transduction enhancer
Chemical Name: (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Teniposide

Teniposide is a DNA topoisomerase II inhibitor and viral transduction enhancer. It induces breaks in double-stranded DNA and prevents DNA repair. Teniposide enhances transduction of recombinant adeno-associated virus 2 (rAAV2) by up to 40-fold in human cells in vitro and by 100-fold in vivo at 24 h post-transduction.

Technical Data for Teniposide

M. Wt 656.66
Formula C32H32O13S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 29767-20-2
PubChem ID 452548
InChI Key NRUKOCRGYNPUPR-QBPJDGROSA-N
Smiles [H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@H]2O[C@]1([H])O[C@]2([H])CO[C@H](O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Teniposide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 65.67 100

Preparing Stock Solutions for Teniposide

The following data is based on the product molecular weight 656.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.61 mL 15.23 mL
5 mM 0.3 mL 1.52 mL 3.05 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Teniposide

References are publications that support the biological activity of the product.

Nicolson et al (2016) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 90 7019 PMID: 27147738

Yusenko et al (2018) A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Sci.Rep. 8 13159 PMID: 30177851

If you know of a relevant reference for Teniposide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all DNA Topoisomerase Inhibitors

Keywords: Teniposide, Teniposide supplier, DNA, topoisomerase, II, inhibitors, viral, transduction, enhancers, adeno-associated, virus, 2, Viral, Transduction, Enhancers, Topoisomerase, 6975, Tocris Bioscience

Citations for Teniposide

Citations are publications that use Tocris products.

Currently there are no citations for Teniposide. Do you know of a great paper that uses Teniposide from Tocris? Please let us know.

Reviews for Teniposide

There are currently no reviews for this product. Be the first to review Teniposide and earn rewards!

Have you used Teniposide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.