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Submit ReviewTFMPP hydrochloride
Description: 5-HT1B partial agonist
Chemical Name: N-(3-Trifluoromethylphenyl)piperazine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for TFMPP hydrochloride
Partial agonist with some preference for 5-HT1B receptors; displays similar potency at 5-HT1A and 5-HT2C receptors.
Technical Data for TFMPP hydrochloride
| M. Wt | 266.69 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 16015-69-3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TFMPP hydrochloride
Certificate of Analysis is currently unavailable on-line.
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References for TFMPP hydrochloride
References are publications that support the biological activity of the product.
Chaouloff et al (1998) GR 127935 and (+)-WAY 100135 do not affect TFMPP-induced inhibition of 5-HT synthesis in the midbrain and hippocampus of Wistar-Kyoto rats. Neuropharmacology 37 1159 PMID: 9833646
Lucki et al (1989) Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 249 155 PMID: 2709329
Schoeffter and Hoyer (1989) Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn Schmiedebergs Arch.Pharmacol. 339 675 PMID: 2770889
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Keywords: TFMPP hydrochloride, TFMPP hydrochloride supplier, 5-HT1B, Receptors, 5-HT-Related, 0968, Tocris Bioscience
Citations for TFMPP hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.