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Submit ReviewTGN 020
Description: Aquaporin 4 (AQP4) channel blocker
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for TGN 020
TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
Compound Libraries for TGN 020
TGN 020 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for TGN 020
| M. Wt | 206.22 |
| Formula | C8H6N4OS |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 51987-99-6 |
| PubChem ID | 4173511 |
| InChI Key | AGEGZHOPKZFKBP-UHFFFAOYSA-N |
| Smiles | O=C(NC1=NN=CS1)C2=CN=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TGN 020
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.12 | 20 |
Preparing Stock Solutions for TGN 020
The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 24.25 mL | 121.23 mL | 242.46 mL |
| 1 mM | 4.85 mL | 24.25 mL | 48.49 mL |
| 2 mM | 2.42 mL | 12.12 mL | 24.25 mL |
| 10 mM | 0.48 mL | 2.42 mL | 4.85 mL |
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Product Datasheets for TGN 020
References for TGN 020
References are publications that support the biological activity of the product.
Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301
Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267
Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629
If you know of a relevant reference for TGN 020, please let us know.
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Keywords: TGN 020, TGN 020 supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Aquaporins, 5425, Tocris Bioscience
2 Citations for TGN 020
Citations are publications that use Tocris products. Selected citations for TGN 020 include:
Wang et al (2017) Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1. J Biol Chem 292 8291 PMID: 28360106
Harrison et al (2020) Impaired glymphatic function and clearance of tau in an Alzheimer's disease model. Brain 143 2576 PMID: 32705145
Do you know of a great paper that uses TGN 020 from Tocris? Please let us know.
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