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Description: Potent dCTP pyrophosphatase 1 inhibitor
Chemical Name: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
Purity: ≥98% (HPLC)
Biological Activity for TH 1217
TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor (IC50 = 47 nM).
TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.
Licensing Information
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.
Technical Data for TH 1217
| M. Wt | 491.09 |
| Formula | C20H17BCl2N4O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1862212-48-3 |
| PubChem ID | 137919863 |
| InChI Key | HWFRCQHNILGMLL-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TH 1217
References for TH 1217
References are publications that support the biological activity of the product.
Llona-Minguez et al (2016) Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1. J.Med.Chem. 59 1140 PMID: 26771665
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Keywords: TH 1217, TH 1217 supplier, TH1217, XTP3TPA, dCTP1, pyrophosphatase, diphosphatase, 1, inhibitors, inhibits, potent, nucleotidohydrolase, Other, Hydrolases, 6522, Tocris Bioscience
Citations for TH 1217
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Currently there are no citations for TH 1217.
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