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Submit ReviewTH 588
Description: Potent MTH1 inhibitor
Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Biological Activity for TH 588
TH 588 is a potent MTH1 inhibitor (IC50 = 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice.
Licensing Information
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.
Technical Data for TH 588
| M. Wt | 295.17 |
| Formula | C13H12Cl2N4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1609960-31-7 |
| PubChem ID | 73389731 |
| InChI Key | PNMYJIOQIAEYQL-UHFFFAOYSA-N |
| Smiles | NC1=NC(C2=C(Cl)C(Cl)=CC=C2)=CC(NC3CC3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TH 588
References for TH 588
References are publications that support the biological activity of the product.
Gad et al (2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508 215 PMID: 24695224
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Keywords: TH 588, TH 588 supplier, TH588, MTH1, MutT, homolog-1, inhibitors, inhibits, potent, NUDT1, (MTH1), 5334, Tocris Bioscience
Citations for TH 588
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Currently there are no citations for TH 588.
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