Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTHDOC
Description: Positive modulator of GABAA receptors; endogenous neurosteroid
Chemical Name: (3α,5α)-3,21-Dihydroxypregnan-20-one
Purity: ≥95% (HPLC)
Biological Activity for THDOC
THDOC is a positive modulator of GABAA receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. Endogenous neurosteroid.
Technical Data for THDOC
| M. Wt | 334.49 |
| Formula | C21H34O3 |
| Storage | Store at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 567-02-2 |
| PubChem ID | 91475 |
| InChI Key | CYKYBWRSLLXBOW-SIDISFDHSA-N |
| Smiles | [H][C@@]12CC[C@@H]([C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C)C(CO)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for THDOC
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.45 | 100 | |
| ethanol | 33.45 | 100 |
Preparing Stock Solutions for THDOC
The following data is based on the product molecular weight 334.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.99 mL | 14.95 mL | 29.9 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.98 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.99 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for THDOC
References for THDOC
References are publications that support the biological activity of the product.
Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. BMC.Neurosci. 16 PMID: 25887256
Adams et al (2015) Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. Neuropharmacology. 88 63 PMID: 25278033
If you know of a relevant reference for THDOC, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: THDOC, THDOC supplier, GABAA, receptor, modulators, modulates, positive, neurosteroid, endogenous, Receptors, 6334, Tocris Bioscience
Citations for THDOC
Citations are publications that use Tocris products.
Currently there are no citations for THDOC. Do you know of a great paper that uses THDOC from Tocris? Please let us know.
Reviews for THDOC
There are currently no reviews for this product. Be the first to review THDOC and earn rewards!
Have you used THDOC?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.