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Thiamet G

Cat. No. 4390 4 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent O-GlcNAcase inhibitor
Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
Datasheet
Citations (4)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Thiamet G

Thiamet G is a potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

Technical Data for Thiamet G

M. Wt 248.3
Formula C9H16N2O4S
Storage Store at -20°C
CAS Number 1009816-48-1
PubChem ID 24808478
InChI Key PPAIMZHKIXDJRN-FMDGEEDCSA-N
Smiles CCNC2=N[C@]1([H])[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]([H])1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Thiamet G

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.41 50

Preparing Stock Solutions for Thiamet G

The following data is based on the product molecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.05 mL 40.27 mL 80.55 mL
2.5 mM 1.61 mL 8.05 mL 16.11 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
25 mM 0.16 mL 0.81 mL 1.61 mL

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Product Datasheets for Thiamet G

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Thiamet G

References are publications that support the biological activity of the product.

Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483 PMID: 18587388

Zhu et al (2018) Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway ACS Chem.Neurosci. 9 1366 PMID: 29460617

If you know of a relevant reference for Thiamet G, please let us know.

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Keywords: Thiamet G, Thiamet G supplier, glycosidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, O-GlcNAcase, ThiametG, Other, Hydrolases, 4390, Tocris Bioscience

4 Citations for Thiamet G

Citations are publications that use Tocris products. Selected citations for Thiamet G include:

Jonathan C et al (2015) Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice. Nat Neurosci 18 1183-9 PMID: 26192747

Maury et al (2013) Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation. Stem Cell Res 11 926 PMID: 23859804

Taparra et al (2018) O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest 128 4924 PMID: 30130254

Hayakawa et al (2013) Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem 288 17099 PMID: 23625921

Do you know of a great paper that uses Thiamet G from Tocris? Please let us know.

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