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Thioridazine hydrochloride

Cat. No. 3070 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Dopamine receptor antagonist; antipsychotic
Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Thioridazine hydrochloride

Thioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.

Technical Data for Thioridazine hydrochloride

M. Wt 407.04
Formula C21H26N2S2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 130-61-0
PubChem ID 66062
InChI Key NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Smiles CN(CCCC4)C4CCN2C3=C(C=CC(SC)=C3)SC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Thioridazine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.53 75
DMSO 40.7 100

Preparing Stock Solutions for Thioridazine hydrochloride

The following data is based on the product molecular weight 407.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.28 mL 24.57 mL
5 mM 0.49 mL 2.46 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for Thioridazine hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Thioridazine hydrochloride

References are publications that support the biological activity of the product.

Merck Index 13 9435

Sachlos et al (2012) Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print PMID: 22632761

Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print PMID: 22460505

If you know of a relevant reference for Thioridazine hydrochloride, please let us know.

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Keywords: Thioridazine hydrochloride, Thioridazine hydrochloride supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Non-selective, Cancer, Stem, Cells, Cell, Differentiation, 3070, Tocris Bioscience

1 Citation for Thioridazine hydrochloride

Citations are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:

Chigaev et al (2011) Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem 286 5455 PMID: 21131351

Do you know of a great paper that uses Thioridazine hydrochloride from Tocris? Please let us know.

Reviews for Thioridazine hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.