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Submit ReviewTianeptine sodium salt
Description: Selective facilitator of 5-HT uptake; antidepressant
Chemical Name: 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt
Purity: ≥99% (HPLC)
Biological Activity for Tianeptine sodium salt
Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
Technical Data for Tianeptine sodium salt
| M. Wt | 458.93 |
| Formula | C21H24ClN2NaO4S |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 30123-17-2 |
| PubChem ID | 23663953 |
| InChI Key | ZLBSUOGMZDXYKE-UHFFFAOYSA-M |
| Smiles | [Na+].CN1C2=CC=CC=C2C(NCCCCCCC([O-])=O)C2=CC=C(Cl)C=C2S1(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tianeptine sodium salt
References for Tianeptine sodium salt
References are publications that support the biological activity of the product.
Kato and Weitsch (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clin.Neuropharmacol. 11 S43 PMID: 3052825
Uzbay et al (1999) Analgesic effect of tianeptine in mice. Life Sci. 64 1313 PMID: 10227587
Plaisant et al (2003) Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology 44 801 PMID: 12681378
Mennini et al (1987) Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmied.Arch.Pharmacol. 336 478
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Keywords: Tianeptine sodium salt, Tianeptine sodium salt supplier, Selective, facilitator, 5-HT, reuptake, antidepressant, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 1972, Tocris Bioscience
2 Citations for Tianeptine sodium salt
Citations are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nature 40 766 PMID: 25249058
Makani et al (2013) Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells. Mol Cell Endocrinol 381 175 PMID: 23933152
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.