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Submit ReviewTMN 355
Description: Cyclophilin A inhibitor
Chemical Name: 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
Purity: ≥98% (HPLC)
Biological Activity for TMN 355
TMN 355 is a potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).
Technical Data for TMN 355
| M. Wt | 380.8 |
| Formula | C21H14ClFN2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1186372-20-2 |
| PubChem ID | 44249042 |
| InChI Key | SFNLLCUAISZNRV-UHFFFAOYSA-N |
| Smiles | ClC1=C(C(NC(NC2C(C=CC=C4)=C4C3=C2C=CC=C3)=O)=O)C(F)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TMN 355
References for TMN 355
References are publications that support the biological activity of the product.
Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295 PMID: 19691347
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Keywords: TMN 355, TMN 355 supplier, TMN355, cyclophilin, a, cypA, immunosuppressants, immunophilins, ppiase, inhibitors, inhibits, Other, Isomerases, 4152, Tocris Bioscience
2 Citations for TMN 355
Citations are publications that use Tocris products. Selected citations for TMN 355 include:
Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777 PMID: 27652979
Ke et al (2020) Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner. Front Cell Dev Biol 8 784 PMID: 32903542
Reviews for TMN 355
Average Rating: 5 (Based on 1 Review.)
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We used TMN 355 to inhibit response for our study.
By
Anonymous on 02/20/2019
Species: Human
Cyclophilin A is secreted from these monocytes, endothelial cells and vascular smooth muscle cells in response to inflammatory stimuli such as hyperglycemia, hypoxia, infection and oxidative stress.We used TMN 355 to inhibit such response for our study.
