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Submit ReviewTMPH hydrochloride
Discontinued Product
2438 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
Description: Neuronal nAChR antagonist
Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate
Purity: ≥98% (HPLC)
Biological Activity for TMPH hydrochloride
TMPH hydrochloride is a potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
Licensing Information
Sold under license from the University of Florida Research Foundation Inc.
Technical Data for TMPH hydrochloride
| M. Wt | 305.88 |
| Formula | C16H31NO2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 849461-91-2 |
| PubChem ID | 16079014 |
| InChI Key | XIDDVJIJIFWGIX-UHFFFAOYSA-N |
| Smiles | CC1(C)NC(C)(C)CC(OC(CCCCCC)=O)C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TMPH hydrochloride
References for TMPH hydrochloride
References are publications that support the biological activity of the product.
Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116
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Keywords: TMPH hydrochloride, TMPH hydrochloride supplier, Neuronal, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), 2438, Tocris Bioscience
2 Citations for TMPH hydrochloride
Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
Peng et al (2013) Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol 84 459 PMID: 23839567
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.