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Description: Potent, selective P2X antagonist
Chemical Name: 2¢,3¢-O-(2,4,6-Trinitrophenyl)adenosine-5¢-triphosphate
Biological Activity for TNP-ATP
High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and P2X2/3 receptors with IC50 values of 6, 0.9, and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
Technical Data for TNP-ATP
| M. Wt | 780.04 |
| Formula | C16H12N8O19P3 Li3Na2 |
| Storage | Desiccate at -20°C |
| CAS Number | 61368-63-6 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TNP-ATP
Certificate of Analysis is currently unavailable on-line.
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References for TNP-ATP
References are publications that support the biological activity of the product.
Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959
Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509 411 PMID: 9575290
Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197
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Keywords: TNP-ATP, TNP-ATP supplier, High, affinity, selective, P2X, receptor, antagonist., Inhibits, ATP-induced, currents, in, cells, expressing, P2X1, P2X3, and, P2X2/3, receptors, with, IC50, values, of, 6, 0.9, 7, nM, respectively., Displays, 1000-fold, selectivity, over, P2X2, P2X4, P2X7., Receptors, 1294, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.