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Description: Bioactive compound library for high-throughput screening, high-content screening, target validation and assay development; comprised of 1280 biologically active compounds (15 μL 10 mM DMSO solutions)
Biological Activity for Tocriscreen 2.0 Micro
Tocriscreen 2.0 Micro is a a library of 1280 biologically active compounds from the Tocris catalog. The compounds within this bioactive compound library cover a wide range of pharmacological targets and research areas. Compounds are supplied pre-dissolved in 15 μL 10 mM DMSO solutions. A larger volume is available as Tocriscreen 2.0 Mini (Cat. No. 7151).
This library replaces the Tocriscreen Plus Micro (Cat. No. 6455).
For more information on the Tocriscreen 2.0 Compound Libraries, please download our informative flyer.
If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.
Key Format and Product Details for Tocriscreen 2.0 Micro
- 96-well microplate format with peelable foil seal
- Compounds arranged 80 per plate with 16 plates per library
- Pre-dissolved in DMSO
- Many compounds are exclusive to Tocris
- Unique library with low overlap
- Full chemical and biological data available
- Exceptional purity
Note: Due to the small volume of this product, please ensure the liquid has settled to the bottom of the well before removing the foil seal.
- This library is supplied in a Corning Microplate; recommended centrifugation for this plate is 1000g or less
The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of molecular targets; 7-TM receptors (GPCRs; 27%), non-kinase enzymes (21%), kinases including enzyme-linked receptors (20%), ion channels (13%), cell biology targets (9%), nuclear receptors (6%), and transporters and other pharmacological targets (5%).
Request Compound List
To request a list of the compounds available in the Tocriscreen 2.0 Micro please click the request tile below. Compound lists can be provided in Excel or SD format.
Technical Data for Tocriscreen 2.0 Micro
| Storage | Store at -20°C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tocriscreen 2.0 Micro
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
Please contact Customer Service
References for Tocriscreen 2.0 Micro
References are publications that support the biological activity of the product.
Li et al (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research. 21 196 PMID: 20956998
Beacham et al (2010) Cell-based potassium ion channel screening using the FluxORTM assay. J.Biomol.Screen. 15 44 PMID: 20208034
Hattori et al (2010) Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc.Natl.Acad.Sci.USA. 107 3546 PMID: 20142487
Li et al (2015) Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. Cell Stem Cell. 17 195 PMID: 26253201
Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142 PMID: 25658371
If you know of a relevant reference for Tocriscreen 2.0 Micro, please let us know.
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11 Citations for Tocriscreen 2.0 Micro
Citations are publications that use Tocris products. Selected citations for Tocriscreen 2.0 Micro include:
Fallon et al (2024) Development of a high-throughput screening platform to identify new therapeutic agents for Medulloblastoma Group 3. SLAS Discov. 29 100147 PMID: 38355016
Cetin et al (2024) A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer. Cell Chem.Biol. PMID: 39043186
Pals et al (2023) A quenched size-expanded nucleotide reports activity of the leukemia biomarker Terminal deoxynucleotidyl Transferase (TdT). Angew.Chem.Int.Ed.Engl. 62 e202302796 PMID: 36880583
Parijat et al (2023) Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays. Sci.Rep. 13 5216 PMID: 36997544
Benmerah et al (2023) Repurposing small molecules for nephronophthisis and related renal ciliopathies. Kidney Int. 104 245 PMID: 37244473
Kim et al (2023) Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell 30 973 PMID: 37339636
Forfar et al (2022) Identification of a novel specific small-molecule melanocortin-2-receptor antagonist. Endocr Connect 11 e220338 PMID: 36515667
Gull et al (2022) Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery. Cold Spring Harb.Protoc. PMID: 36180216
Abduljalil et al (2022) Screening the TocriscreenTM bioactive compound library in search for inhibitors of Candida biofilm formation. APMIS 130 568 PMID: 3579108
Lee & Jeong et al (2022) NMDA Receptor Antagonists Degrade Lipofuscin via Autophagy in Human Retinal Pigment Epithelial Cells Medicina (Kaunas) 58 1129 PMID: 36013596
Liu et al (2020) Ultrasensitive small molecule fluorogenic probe for human heparanase. Chem Sci 12 239 PMID: 34163592
Do you know of a great paper that uses Tocriscreen 2.0 Micro from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Tocriscreen Compound Libraries
This brochure gives an overview of the unique TocriscreenTM bioactive compound library range, including
- Tocriscreen 2.0 Compound Library
- Focused Tocriscreen Libraries
- Tocriscreen FDA-approved Drug Library
- Tocriscreen PRO Custom Service