Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTocriscreen GPCR Compound Library
Description: A bioactive compound library of 240 GPCR compounds (100 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening, target validation and assay development
Biological Activity for Tocriscreen GPCR Compound Library
Tocriscreen GPCR Compound Library is a library of 240 compounds (100 μl, 10 mM) for GPCR research. Contains compounds that target >30 types of GPCR, including peptide receptors, 5-HT receptors, chemokine receptors, adenosine receptors, adrenergic receptors and more. Adapted for popular techniques in drug discovery and cell biology research, including high throughput screening, high content screening, target validation and assay development. Please view the GPCR tree image for a closer look at the pharmacological diversity of this compound library.
If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.
Scientific Data
Class A GPCR phylogenetic tree illustrating the pharmacological diversity of the Tocriscreen GPCR Compound Library. The 240 compounds in the Tocriscreen GPCR Compound Library target over 120 GPCRs. Targets are evenly spread across all the GPCR classes with a particular focus on class A, mixing well-established targets such as 5-HT and adenosine receptors, as well as orphan GPCRs such as GPR35 and GPR171. To view a larger PDF version of this image, please click on the ‘GPCR tree’ link in the product description.Adapted from GPCRdb (www.gpcrdb.org/ligand/coverage).
Chemical diversity of the Tocriscreen GPCR Compound Library. The image shows the overlapping chemical space of the 240 compounds in the Tocriscreen GPCR Compound Library (green dots) in relation to the chemical space occupied by the ChEMBL GPCR compound Chemical Space* (grey dots). Each dot represents a unique fingerprint generated from each compound’s 3D molecular structure. The even distribution of the fingerprints of the compounds in the Tocriscreen GPCR Compound Library highlights the chemical diversity of this library.*The ChEMBL GPCR compound Chemical Space used for this study is defined as a subset of ChEMBL with activities < 1 μM on any of the GPCRs listed in ChEMBL, with a molecular weight between 150 and 550 Da, AlogP between (-2) and 6 and a maximum of one Lipinski rule of 5 violation. This subset contains over 77k compounds.
Key Format and Product Details for Tocriscreen GPCR Compound Library
- 96-well racks with Matrix storage tubes & SepraSeal caps
- Pre-dissolved in DMSO
- Compounds arranged 80 per rack with 3 racks per library
- Many compounds are exclusive to Tocris
- Full chemical and biological data available
- Exceptional purity
Major GPCR subfamilies covered by Tocriscreen GPCR Library. Peptide Receptors (20%), 5-HT Receptors (10%), Chemokine Receptors (8%), Adenosine Receptors (7%), Adrenergic Receptors (7%), Dopamine Receptors (6%), mGlu Receptors (5%), Opioid Receptors (4%), Muscarinic Receptors (4%), S1P Receptors (4%), Other (26%).
Request Compound List
To request a list of the compounds available in the Tocriscreen GPCR Compound Library please click the request tile below. Compound lists can be provided in Excel or SD format.
Technical Data for Tocriscreen GPCR Compound Library
| Storage | Store at -20°C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tocriscreen GPCR Compound Library
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
Please contact Customer Service
References for Tocriscreen GPCR Compound Library
References are publications that support the biological activity of the product.
If you know of a relevant reference for Tocriscreen GPCR Compound Library, please let us know.
View Related Products by Target
Keywords: Tocriscreen GPCR Compound Library, Tocriscreen GPCR Compound Library supplier, tocriscreen, gpcr, 7tm, g-protein, coupled, receptors, library, toolbox, compound, libraries, high-throughput, screening, high-content, chemical, biology, applications, Tocriscreen, Compound, Libraries, 8100, Tocris Bioscience
Citations for Tocriscreen GPCR Compound Library
Citations are publications that use Tocris products.
Currently there are no citations for Tocriscreen GPCR Compound Library. Do you know of a great paper that uses Tocriscreen GPCR Compound Library from Tocris? Please let us know.
Reviews for Tocriscreen GPCR Compound Library
There are currently no reviews for this product. Be the first to review Tocriscreen GPCR Compound Library and earn rewards!
Have you used Tocriscreen GPCR Compound Library?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Tocriscreen Compound Libraries
This brochure gives an overview of the unique TocriscreenTM bioactive compound library range, including
- Tocriscreen 2.0 Compound Library
- Focused Tocriscreen Libraries
- Tocriscreen FDA-approved Drug Library
- Tocriscreen PRO Custom Service