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Submit ReviewTomoxetine hydrochloride
Description: Potent and selective noradrenalin re-uptake inhibitor
Alternative Names: Atomoxetine,LY 139603
Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Tomoxetine hydrochloride
Tomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.
Technical Data for Tomoxetine hydrochloride
| M. Wt | 291.82 |
| Formula | C17H21NO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 82248-59-7 |
| PubChem ID | 54840 |
| InChI Key | LUCXVPAZUDVVBT-UNTBIKODSA-N |
| Smiles | Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tomoxetine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.59 | 50 with gentle warming |
Preparing Stock Solutions for Tomoxetine hydrochloride
The following data is based on the product molecular weight 291.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.85 mL | 34.27 mL | 68.54 mL |
| 2.5 mM | 1.37 mL | 6.85 mL | 13.71 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.85 mL |
| 25 mM | 0.14 mL | 0.69 mL | 1.37 mL |
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Product Datasheets for Tomoxetine hydrochloride
References for Tomoxetine hydrochloride
References are publications that support the biological activity of the product.
Wong et al (1982) A new inhibitor of NE uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 222 61 PMID: 6123593
Bymaster et al (2002) Atomoxetine increases extracellular levels of NE and DA in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 699 PMID: 12431845
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Keywords: Tomoxetine hydrochloride, Tomoxetine hydrochloride supplier, Potent, selective, noradrenaline, noradrenalin, reuptake, inhibitors, inhibits, Transporters, adrenaline, adrenalin, NET, Adrenergic, Monoamine, Neurotransmitter, LY139603, Atomoxetine, LY, 139603, 2011, Tocris Bioscience
5 Citations for Tomoxetine hydrochloride
Citations are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:
Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. J Neurosci 352 53 PMID: 25332454
Achterberg et al (2015) Methylphenidate and atomox. inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats. Psychopharmacology (Berl) 35 161 PMID: 25568111
Finnema et al (2015) Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain. Toxins (Basel) 18 PMID: 25522417
Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. Int J Neuropsychopharmacol 231 2671 PMID: 24481568
Kobayashi et al (2010) Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine. Neuropsychopharmacology 35 1560 PMID: 20393461
Do you know of a great paper that uses Tomoxetine hydrochloride from Tocris? Please let us know.
Reviews for Tomoxetine hydrochloride
Average Rating: 4 (Based on 1 Review.)
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Arrived next day, quality.
By
Shannon Ballard on 07/24/2020
Assay Type: In Vivo
Species: Rat
diluted into saline solution to be injected into animals for observation of behavioral effects