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Submit ReviewTracazolate hydrochloride
Description: Allosteric modulator of GABAA receptors
Alternative Names: ICI 136753
Chemical Name: 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Tracazolate hydrochloride
Tracazolate hydrochloride is a GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.
Technical Data for Tracazolate hydrochloride
| M. Wt | 340.85 |
| Formula | C16H24N4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1135210-68-2 |
| PubChem ID | 24871267 |
| InChI Key | TUIXDPUEMQXVHO-UHFFFAOYSA-N |
| Smiles | Cl.CCCCNC1=C2C=NN(CC)C2=NC(C)=C1C(=O)OCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tracazolate hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 34.09 | 100 |
Preparing Stock Solutions for Tracazolate hydrochloride
The following data is based on the product molecular weight 340.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.93 mL | 14.67 mL | 29.34 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.87 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.93 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets for Tracazolate hydrochloride
References for Tracazolate hydrochloride
References are publications that support the biological activity of the product.
Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315 PMID: 6121710
Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323 PMID: 6121711
Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861 PMID: 11901225
If you know of a relevant reference for Tracazolate hydrochloride, please let us know.
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Keywords: Tracazolate hydrochloride, Tracazolate hydrochloride supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, ICI, 136753, 1558, Tocris Bioscience
1 Citation for Tracazolate hydrochloride
Citations are publications that use Tocris products. Selected citations for Tracazolate hydrochloride include:
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci 34 10219 PMID: 25080584
Do you know of a great paper that uses Tracazolate hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.