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Description: nNOS/iNOS inhibitor
Chemical Name: 1-(2-Trifluoromethylphenyl)imidazole
Purity: ≥99% (HPLC)
Biological Activity for TRIM
A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.
Technical Data for TRIM
| M. Wt | 212.17 |
| Formula | C10H7F3N2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 25371-96-4 |
| PubChem ID | 1359 |
| InChI Key | WZBWBNCQUTXYEL-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C1=C(C=CC=C1)N1C=CN=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TRIM
References for TRIM
References are publications that support the biological activity of the product.
Handy et al (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 116 2349 PMID: 8581267
Handy et al (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 119 423 PMID: 8886430
Tooker et al (2013) Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J.Neurosci. 33 19176 PMID: 24305814
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Keywords: TRIM, TRIM supplier, nNOS/iNOS, inhibitors, inhibits, Non-Selective, NOS, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Non-selective, 0919, Tocris Bioscience
1 Citation for TRIM
Citations are publications that use Tocris products. Selected citations for TRIM include:
Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161
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