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Description: Binds voltage-dependent anion channel (VDAC)
Alternative Names: Olesoxime
Chemical Name: Cholest-4-en-3-one oxime
Purity: ≥98% (HPLC)
Biological Activity for TRO 19622
TRO 19622 is a neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.
Technical Data for TRO 19622
| M. Wt | 399.65 |
| Formula | C27H45NO |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 22033-87-0 |
| PubChem ID | 76971721 |
| InChI Key | QNTASHOAVRSLMD-GYKMGIIDSA-N |
| Smiles | [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TRO 19622
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.98 | 50 | |
| ethanol | 7.99 | 20 |
Preparing Stock Solutions for TRO 19622
The following data is based on the product molecular weight 399.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5 mL | 25.02 mL | 50.04 mL |
| 2.5 mM | 1 mL | 5 mL | 10.01 mL |
| 5 mM | 0.5 mL | 2.5 mL | 5 mL |
| 25 mM | 0.1 mL | 0.5 mL | 1 mL |
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Product Datasheets for TRO 19622
References for TRO 19622
References are publications that support the biological activity of the product.
Bordet et al (2007) Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J.Pharmacol.Exp.Ther. 322 709 PMID: 17496168
If you know of a relevant reference for TRO 19622, please let us know.
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Keywords: TRO 19622, TRO 19622 supplier, Neuroprotective, neuroregenerative, Binds, voltage-dependent, anion, VDAC, Channels, modulators, Other, TRO19622, mitochondrial, pore, MPTP, olesoxime, spinal, muscular, atrophy, SMA, Olesoxime, Channel, Modulators, Miscellaneous, Compounds, 2906, Tocris Bioscience
2 Citations for TRO 19622
Citations are publications that use Tocris products. Selected citations for TRO 19622 include:
Skals et al (2014) Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore. J Biol Chem 289 19098 PMID: 24860098
González et al (2016) Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. Front Neurosci 126 1023 PMID: 26878172
Do you know of a great paper that uses TRO 19622 from Tocris? Please let us know.
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