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Submit ReviewTRPC6-PAM-C20
Description: Selective positive allosteric modulator (PAM) of TRPC6
Chemical Name: 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Biological Activity for TRPC6-PAM-C20
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.
Technical Data for TRPC6-PAM-C20
| M. Wt | 363.41 |
| Formula | C22H21NO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 667427-75-0 |
| PubChem ID | 1081484 |
| InChI Key | SNICUMZYPOCXCO-UHFFFAOYSA-N |
| Smiles | COC1=C(OC)C=C2C(CC(C)(C)N=C2C2=CC3=CC=CC=C3OC2=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TRPC6-PAM-C20
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.34 | 100 | |
| ethanol | 7.27 | 20 |
Preparing Stock Solutions for TRPC6-PAM-C20
The following data is based on the product molecular weight 363.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.76 mL | 27.52 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.75 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets for TRPC6-PAM-C20
References for TRPC6-PAM-C20
References are publications that support the biological activity of the product.
Häfner et al (2019) Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium 78 26 PMID: 30594060
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Keywords: TRPC6-PAM-C20, TRPC6-PAM-C20 supplier, Transient, receptor, potential, canonical, TRPC6, positive, allosteric, modulators, modulates, PAM, platelet, aggregation, TRPC, 6875, Tocris Bioscience
1 Citation for TRPC6-PAM-C20
Citations are publications that use Tocris products. Selected citations for TRPC6-PAM-C20 include:
Anastasia et al (2022) New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice. Int J Mol Sci 23 PMID: 36362339
Do you know of a great paper that uses TRPC6-PAM-C20 from Tocris? Please let us know.
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