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Submit ReviewTubastatin A hydrochloride
Description: Potent HDAC6 inhibitor
Chemical Name: N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Tubastatin A hydrochloride
Tubastatin A hydrochloride is a potent HDAC6 inhibitor (IC50 = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC50 values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in a mouse model of Charcot-Marie-Tooth disease.
Technical Data for Tubastatin A hydrochloride
| M. Wt | 371.86 |
| Formula | C20H21N3O2.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1310693-92-5 |
| PubChem ID | 57336514 |
| InChI Key | LJTSJTWIMOGKRJ-UHFFFAOYSA-N |
| Smiles | CN1CCC2=C(C3=CC=CC=C3N2CC4=CC=C(C(NO)=O)C=C4)C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tubastatin A hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.72 | 10 with gentle warming |
Preparing Stock Solutions for Tubastatin A hydrochloride
The following data is based on the product molecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.89 mL | 134.46 mL | 268.92 mL |
| 0.5 mM | 5.38 mL | 26.89 mL | 53.78 mL |
| 1 mM | 2.69 mL | 13.45 mL | 26.89 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
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Product Datasheets for Tubastatin A hydrochloride
References for Tubastatin A hydrochloride
References are publications that support the biological activity of the product.
Butler et al (2010) Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A J.Am.Chem.Soc. 132 10842
d'Ydewalle et al (2011) HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nature medicine 7 26 PMID: 21785432
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Keywords: Tubastatin A hydrochloride, Tubastatin A hydrochloride supplier, HDAC6, potent, inhibitors, inhibits, histone, deacetylases, Class, II, HDACs, 6270, Tocris Bioscience
1 Citation for Tubastatin A hydrochloride
Citations are publications that use Tocris products. Selected citations for Tubastatin A hydrochloride include:
Steven L et al (2022) INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. Nat Commun 13 6037 PMID: 36229429
Do you know of a great paper that uses Tubastatin A hydrochloride from Tocris? Please let us know.
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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