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U 104

Cat. No. 4540 Submit a Review Datasheet / COA / SDS

Discontinued Product

4540 has been discontinued.

View all Carbonic Anhydrases products.
Description: Potent carbonic anhydrase (CA) IX and XII inhibitor
Chemical Name: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for U 104

U 104 is a potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.

Technical Data for U 104

M. Wt 309.32
Formula C13H12FN3O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 178606-66-1
PubChem ID 310360
InChI Key YJQZNWPYLCNRLP-UHFFFAOYSA-N
Smiles FC1=CC=C(NC(NC2=CC=C(S(=O)(N)=O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for U 104

References are publications that support the biological activity of the product.

Lou et al (2011) Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71 3364 PMID: 21415165

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Citations for U 104

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Currently there are no citations for U 104.

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Literature in this Area

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Cancer Metabolism Research Product Guide

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