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Submit ReviewU 89843A
Description: Positive allosteric modulator of GABAA receptors
Alternative Names: PNU 89843
Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for U 89843A
U 89843A is a positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
Technical Data for U 89843A
| M. Wt | 321.85 |
| Formula | C16H23N5.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 157013-85-9 |
| PubChem ID | 56972182 |
| InChI Key | MNKBXPNQWKUSKU-UHFFFAOYSA-N |
| Smiles | CC2=CC1=C(N3CCCC3)N=C(N4CCCC4)N=C1N2C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for U 89843A
References for U 89843A
References are publications that support the biological activity of the product.
Bundy et al (1995) Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J.Med.Chem. 38 4161 PMID: 7473542
Haesook et al (1995) U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 275 1390 PMID: 8531107
Rohn et al (1996) Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem.Pharmacol. 51 471 PMID: 8619892
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Keywords: U 89843A, U 89843A supplier, Positive, allosteric, modulators, GABAA, receptors, Receptors, U89843A, PNU89843, PAM, PNU, 89843, 2734, Tocris Bioscience
Citations for U 89843A
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.