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Submit ReviewU 99194 maleate
Description: Potent and selective D3 antagonist
Alternative Names: PNU 99194
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate
Purity: ≥98% (HPLC)
Biological Activity for U 99194 maleate
U 99194 maleate is a potent, selective D3 antagonist. Ki values are 160, 2281 and > 10000 nM for human cloned D3, D2 and D4 receptors respectively.
Technical Data for U 99194 maleate
| M. Wt | 393.48 |
| Formula | C17H27NO2.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 234757-41-6 |
| PubChem ID | 11957713 |
| InChI Key | FSIQDESGRQTFNN-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CCCN(CCC)C1CC2=C(C1)C=C(OC)C(OC)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for U 99194 maleate
References for U 99194 maleate
References are publications that support the biological activity of the product.
Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel DA D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187 PMID: 9765337
Clifford and Waddington (1998) Heterogeneity of behavioural profile between three putative selective D3 DA receptor antagonists using an ethologically based approach. Psychopharmacology 136 284 PMID: 9566814
LaHoste et al (2000) DA D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J.Neurosci. 20 6666 PMID: 10964971
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Keywords: U 99194 maleate, U 99194 maleate supplier, Potent, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, U99194, maleate, PNU99194, PNU, 99194, 1357, Tocris Bioscience
2 Citations for U 99194 maleate
Citations are publications that use Tocris products. Selected citations for U 99194 maleate include:
Bastianetto et al (2006) Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci 7 28 PMID: 16573831
Newton et al (2016) Examining the Effects of Sodium Ions on the Binding of Antagonists to DA D 2 and D 3 Receptors PLoS One 11 e0158808 PMID: 27379794
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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