Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewUB 165 fumarate
Discontinued Product
1348 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
Description: Subunit selective nAChR agonist
Chemical Name: 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate
Purity: ≥99% (HPLC)
Biological Activity for UB 165 fumarate
UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.
Licensing Information
Sold with the permission of the University of Bristol
Technical Data for UB 165 fumarate
| M. Wt | 350.8 |
| Formula | C13H15ClN2.C4H4O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| PubChem ID | 71297058 |
| InChI Key | DZFRKSLRKAKJIB-WLHGVMLRSA-N |
| Smiles | [H]OC(=O)\C=C\C(=O)O[H].ClC1=CC=C(C=N1)C1=CCCC2CCC1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UB 165 fumarate
References for UB 165 fumarate
References are publications that support the biological activity of the product.
Sharples et al (2000) UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of DA release from rat striatal synaptosomes. J.Neurosci. 20 2783 PMID: 10751429
Wright et al (1997) Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett. 7 2867
Cao et al (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]DA release. Neuropharmacology 48 72 PMID: 15617729
View Related Products by Target
View Related Products by Product Action
Keywords: UB 165 fumarate, UB 165 fumarate supplier, Subunit, selective, nAChR, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, UB165, 200432-86-6, (Other, Subtypes), 1348, Tocris Bioscience
Citations for UB 165 fumarate
Citations are publications that use Tocris products.
Currently there are no citations for UB 165 fumarate.
Reviews for UB 165 fumarate
There are currently no reviews for this product. Be the first to review UB 165 fumarate and earn rewards!
Have you used UB 165 fumarate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.