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Submit ReviewUBP 282
Description: Non-NMDA iGluR antagonist; distinguishes between motoneuron and dorsal root kainate receptors
Alternative Names: 3-CBW
Chemical Name: (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
Purity: ≥98% (HPLC)
Biological Activity for UBP 282
AMPA and kainate receptor antagonist. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres.
Technical Data for UBP 282
| M. Wt | 333.3 |
| Formula | C15H15N3O6 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 544697-47-4 |
| PubChem ID | 6604912 |
| InChI Key | XLRLZPOBHPIDFX-NSHDSACASA-N |
| Smiles | O=C(C=CN1C[C@H](N)C(O)=O)N(CC2=CC=C(C(O)=O)C=C2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UBP 282
References for UBP 282
References are publications that support the biological activity of the product.
More et al (2002) The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres. Br.J.Pharmacol. 137 1125 PMID: 12429586
More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093 PMID: 12684265
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Keywords: UBP 282, UBP 282 supplier, AMPA/kainate, antagonists, receptors, Glutamate, AMPA, iGluR, Ionotropic, Kainate, UBP282, 3CBW, 3-CBW, Receptors, 1765, Tocris Bioscience
Citations for UBP 282
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