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Discontinued Product
1369 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Group III mGlu antagonist
Chemical Name: α-Methyl-3-methyl-4-phosphonophenylglycine
Purity: ≥99% (HPLC)
Biological Activity for UBP1112
UBP1112 is an a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors).
Technical Data for UBP1112
| M. Wt | 259.2 |
| Formula | C10H14NO5P |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 339526-74-8 |
| PubChem ID | 5022489 |
| InChI Key | LLEOLNUKLKCAFG-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UBP1112
References for UBP1112
References are publications that support the biological activity of the product.
Conway et al (2001) Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorg.Med.Chem.Lett. 11 777 PMID: 11277518
Miller et al (2003) Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. Br.J.Pharmacol. 139 1523 PMID: 12922940
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Keywords: UBP1112, UBP1112 supplier, Group, III, antagonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, UBP, 1112, (Metabotropic), 1369, Tocris Bioscience
2 Citations for UBP1112
Citations are publications that use Tocris products. Selected citations for UBP1112 include:
Govea et al (2012) Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. J Biol Chem 217 130 PMID: 22609935
Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591 PMID: 16920620
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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