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Submit ReviewUCM 707
Description: Potent anandamide transport inhibitor
Chemical Name: (5Z,8Z,11Z,14Z)-N-(3-Furanylmethyl)-5,8,11,14-eicosatetraenamide
Biological Activity for UCM 707
UCM 707 is a potent endocannabinoid transport inhibitor. IC50 values are 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH respectively. Ki values are 4700, 67 and > 5000 nM for CB1, CB2 and VR1 receptors respectively. Potentiates hypokinetic and antinociceptive effects of anandamide in vivo.
Technical Data for UCM 707
| M. Wt | 383.57 |
| Formula | C25H37NO2 |
| Storage | Desiccate at -20°C |
| CAS Number | 390824-20-1 |
| PubChem ID | 10199993 |
| InChI Key | FZNNBSHTNRBBBD-DOFZRALJSA-N |
| Smiles | O=C(NCC1=COC=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UCM 707
References for UCM 707
References are publications that support the biological activity of the product.
Lopez-Rodriguez et al (2003) Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. Eur.J.Med.Chem. 38 403 PMID: 12750028
Lopez-Rodriguez et al (2003) Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. J.Med.Chem. 46 1512 PMID: 12672252
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Keywords: UCM 707, UCM 707 supplier, Potent, anandamide, transporters, inhibitors, inhibits, AMT, Anandamide, cannabinoids, Monoamine, Neurotransmitter, UCM707, Cannabinoid, Transporters, 1966, Tocris Bioscience
Citations for UCM 707
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Currently there are no citations for UCM 707.
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