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Submit ReviewUF 010
Description: Class I HDAC inhibitor
Chemical Name: 4-Bromo-N'-butylbenzohydrazide
Purity: ≥98% (HPLC)
Biological Activity for UF 010
Class I HDAC inhibitor (IC50 values are 0.06, 0.1, 0.5 and 1.5 μM for HDACs 3, 2, 1 and 8, respectively). Exhibits >6-fold selectivity over other HDACs. Induces accumulation of acetylated histones in HCT116 cells in vitro. Inhibits proliferation of a range of cancer cell lines. Arrests cells at G1/S transition.
Technical Data for UF 010
| M. Wt | 271.15 |
| Formula | C11H15BrN2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 537672-41-6 |
| PubChem ID | 4596836 |
| InChI Key | BVQCFCYPFJOOAV-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C(NNCCCC)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UF 010
References for UF 010
References are publications that support the biological activity of the product.
Wang et al (2015) Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem.Biol. 22 273 PMID: 25699604
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Keywords: UF 010, UF 010 supplier, UF010, histone, deacetylase, inhibitors, inhibits, HDAC, classI, cancer, proliferation, cell, cycle, arrest, antiproliferative, epigenetics, Class, I, HDACs, 5588, Tocris Bioscience
Citations for UF 010
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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