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Description: Potent G9a and GLP inhibitor
Chemical Name: 7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
Purity: ≥98% (HPLC)
Biological Activity for UNC 0224
UNC 0224 is a potent G9a and GLP inhibitor (IC50 values are 15 and 20 nM in a ThioGlo assay, respectively). Exhibits >1000-fold selectivity for G9a over SET7, SET8 and SET9. UNC 0224 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
Technical Data for UNC 0224
| M. Wt | 485.67 |
| Formula | C26H43N7O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1197196-48-7 |
| PubChem ID | 44251522 |
| InChI Key | XIVUGRBSBIXXJE-UHFFFAOYSA-N |
| Smiles | CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UNC 0224
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 48.57 | 100 | |
| DMSO | 48.57 | 100 |
Preparing Stock Solutions for UNC 0224
The following data is based on the product molecular weight 485.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.3 mL | 20.59 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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Product Datasheets for UNC 0224
References for UNC 0224
References are publications that support the biological activity of the product.
Liu et al (2009) Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem. 52 7950 PMID: 19891491
Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683
If you know of a relevant reference for UNC 0224, please let us know.
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Keywords: UNC 0224, UNC 0224 supplier, UNC0224, potent, inhibitors, inhibits, histone, lysine, methyltransferases, htmase, G9a, epigenetics, GLP, induced, pluripotent, stem, cells, reprogramming, iPSC, Lysine, Methyltransferases, G9a/GLP, Stem, Cell, Reprogramming, 3861, Tocris Bioscience
Citations for UNC 0224
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Literature in this Area
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